Suggested Reading

Reviews and Background information:

  1. Hara K, et al: Diabetes Care 2006; 29: 1357-62
  2. Kadowaki T, T Yamauchi, N Kubota, K Hara, K Ueki, K Tobe. Adiponectin and adiponectin receptors in insulin resistance, diabetes and the metabolic syndrome.The Journal of Clinical Investigation 2006. 116 (7): 1784-1792.
  3. Pajvani, UB et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 279: 12152-12162.

Citing the ALPCO Multimeric Adiponectin ELISA:

  1. Kovacova, Z. et al. Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet. European Journal of Endocrinology, Vol 160, Issue 4, 585-592
  2. Liu, D., T. Schuster, M. Baumann, M. Roos, D. Sollinger, J. Lutz, U. Heemann, M. von Eynatten. Comparison of Immunoassays for the Selective Measurement of Human High-Molecular Weight Adiponectin. Clinical Chemistry (2009); Vol 55, no. 3, pp 1-5.
  3. Devaraj S, MM Swarbrick, U Singh, B Adams-Huet, PJ Havel, I Jialal. CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers. Am J Clin Pathol (2008); Vol 129, no. 5, pp 815-22.
  4. Koenen, T.B., L. J.H. van Tits, S. Holewijn, H.L.M. Lemmers, M. den Heijer, A.F.H. Stalenhoef, J. de Graaf. Adiponectin Multimers Distribution in Patients with Familial Combined Hyperlipidemia. Biochemical and Biophysical Research Communications (2008); Vol. 376, no. 1, pp 164-168.
  5. Heidemann, C., Q Sun, RM van Dam, JB Meigs, C Zhang, SS Tworoger, CS Mantzoros, F Hu. Total and High-Molecular Weight Adiponectin and Resistin in Relation to the Risk for Type 2 Diabetes in Women. Annals of Internal Medicine (2008); Vol. 149, no. 5, pp 307-316.
  6. von Eynatten, M, A Hamann, D Twardella, PP Nawroth, H Brenner, D Rothenbacher. Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease. European Heart Journal (2008); 29: 1307-1315.
  7. Liu, Y, R Retnakaran, A Hanley, R Tungtrongchitr, C Shaw, G Sweeney. Total and High Molecular Weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. JCEM (2007); Vol. 92, no. 11, pp 4313-4318.
  8. von Eynatten, M, PM Humbert, A Bluemm, PM Lepper, A Hamann, B Allolio, PP Nawroth, A Bierhaus, KA Dugi. High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men. Atherosclerosis 2008. 199 (1): 123-8.
  9. Haqq, AM, M Muehlbauer, LP Svetkey, CB Newgard, JQ Purnell, SC Grambow, MS Freemark. Altered Distribution of adiponectin isoforms in children with Prader-Willi Syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clinical Endocrinology (2007); Vol. 67 (6): 944-951
  10. Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T. Improved ELISA for Selective Measurement of Adiponectin Multimers and Identification of Adiponectin in Human Cerebrospinal Fluid. Clin Chem. 2007. 53 (8): 1541-4.
  11. Matthias Blüher, Aoife M. Brennan, Theodoros Kelesidis, Jürgen Kratzsch, Mathias Fasshauer, Susan Kralisch, Catherine J. Williams, and Christos S. Mantzoros. Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative evaluation of three assays Diabetes Care 2007. Vol. 30: 280-285.
    1. Catherine J. Williams, Aoife Brennan, Matthias Blüher, and Christos S. Mantzoros Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative Evaluation of Three Assays: Response to von Eynatten et al. Diabetes Care 30: e68
    2. Maximilian von Eynatten, Philipp M. Lepper, and Per M. Humpert.Total and High–Molecular Weight Adiponectin in Relation to Metabolic Variables at Baseline and in Response to an Exercise Treatment Program: Comparative Evaluation of Three Assays: Response to Blüher et al. Diabetes Care 30: e67.
  12. M. M. Swarbrick, I. T. Austrheim-Smith, K. L. Stanhope, M. D. Van Loan & M. R. Ali,B. M. Wolfe, P. J. Havel. Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia 2006. 49 (11): 2552-8.
  13. Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T. Measurement of the High-Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome. Diabetes Care. 2006 Jun;29(6):1357-1362.
  14. Araki, S, K Dobashi, K Kubo, K. Asayama, A Shirahata. High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. JCEM (2006) December; 91: 5113-5116.
  15. Akira Katsuki, Mina Suematsu, Esteban C. Gabazza, Shuichi Murashima, Kaname Nakatani, Kenji Togashi, Yutaka Yano, and Yashuhiro Sumida. Decreased High–Molecular Weight Adiponectin–to–Total Adiponectin Ratio in Sera Is Associated With Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Men With Normal Glucose Tolerance Diabetes Care 29: 2327-2328.
  16. Ebinuma H, Miyazaki O, Yago H, Hara K, Yamauchi T, Kadowaki T. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta (2006). 372 (1-2):47-53.